Thyroid Dynamics

Quite a while back, I posted about the dynamics of the thyroid and its interactions with other systems.

That was a conceptual model; this is a mathematical model. This is a Vensim replication of:

Marisa Eisenberg, Mary Samuels, and Joseph J. DiStefano III

Extensions, Validation, and Clinical Applications of a Feedback Control System Simulator of the Hypothalamo-Pituitary-Thyroid Axis

Background:We upgraded our recent feedback control system (FBCS) simulation model of human thyroid hormone (TH) regulation to include explicit representation of hypothalamic and pituitary dynamics, and up-dated TH distribution and elimination (D&E) parameters. This new model greatly expands the range of clinical and basic science scenarios explorable by computer simulation.

Methods: We quantified the model from pharmacokinetic (PK) and physiological human data and validated it comparatively against several independent clinical data sets. We then explored three contemporary clinical issues with the new model: …

… These results highlight how highly nonlinear feedback in the hypothalamic-pituitary-thyroid axis acts to maintain normal hormone levels, even with severely reduced TSH secretion.

THYROID
Volume 18, Number 10, 2008
DOI: 10.1089=thy.2007.0388

This version is a superset of the authors’ earlier 2006 model, and closely reproduces that with a few parameter changes.

L-T4 Bioequivalence and Hormone Replacement Studies via Feedback Control Simulations

THYROID
Volume 16, Number 12, 2006

The model is used in:

TSH-Based Protocol, Tablet Instability, and Absorption Effects on L-T4 Bioequivalence

THYROID
Volume 19, Number 2, 2009
DOI: 10.1089=thy.2008.0148

This works with any Vensim version:

thyroid 2008 d.mdl

thyroid 2008 d.vpm

The Dynamics of Initiative Success

This is a new replication of a classic model, for the library. The model began in Nelson Repenning’s thesis, and was later published in Organization Science:

A Simulation-Based Approach to Understanding the Dynamics of Innovation Implementation

The history of management practice is filled with innovations that failed to live up to the promise suggested by their early success. A paradox currently facing organizational theory is that the failure of these innovations often cannot be attributed to an intrinsic lack of efficacy. To resolve this paradox, in this paper I study the process of innovation implementation. Working from existing theoretical frameworks, I synthesize a model that describes the process through which participants in an organization develop commitment to using a newly adopted innovation. I then translate that framework into a formal model and analyze it using computer simulation. The analysis suggests three new constructs—reversion, regeneration, and the motivation threshold—characterizing the dynamics of implementation. Taken together, the constructs provide an internally consistent theory of how seemingly rational decision rules can create the apparent paradox of innovations that generate early results but fail to produce sustained benefit.

An earlier version is online here.

This is another nice example of tipping points. In this case, an initiative must demonstrate enough early success to grow its support base. If it succeeds, word of mouth takes its commitment level to 100%. If not, the positive feedbacks run as vicious cycles, and the initiative fails.

When initiatives compete for scarce resources, this creates a success to the successful dynamic, in which an an initiative that demonstrates early success attracts more support, grows commitment faster, and thereby demonstrates more success.

This version is in Ventity, in order to make it easier to handle multiple competing initiatives, with each as a discrete entity. One initialization dataset for the model creates initiatives at random intervals, with success contingent on the environment (other initiatives) prevailing at the time of launch:

This archive contains two versions of the model: “Intervention2” is the first in the paper, with no resource competition. “Intervention5” is the second, with multiple competing initiatives.

Innovation2+5.zip

Feedback and project schedule performance

Yasaman Jalili and David Ford look take a deeper look at project model dynamics in the January System Dynamics Review. An excerpt:
projectloops

Quantifying the impacts of rework, schedule pressure, and ripple effect loops on project schedule performance

Schedule performance is often critical to construction project success. But many times projects experience large unforeseen delays and fail to meet their schedule targets. The failure of large construction projects has enormous economic consequences. …

… the persistence of large project delays implies that their importance has not been fully recognized and incorporated into practice. Traditional project management methods do not explicitly consider the effects of feedback (Pena-Mora and Park, 2001). Project managers may intuitively include some impacts of feedback loops when managing projects (e.g. including buffers when estimating activity durations), but the accuracy of the estimates is very dependent upon the experience and judgment of the scheduler (Sterman, 1992). Owing to the lack of a widely used systematic approach to incorporating the impacts of feedback loops in project management, the interdependencies and dynamics of projects are often ignored. This may be due to a failure of practicing project managers to understand the role and significance of commonly experienced feedback structures in determining project schedule performance. Practitioners may not be aware of the sizes of delays caused by feedback loops in projects, or even the scale of impacts. …

In the current work, a simple validated project model has been used to quantify the schedule impacts of three common reinforcing feedback loops (rework cycle, “haste makes waste”, and ripple effects) in a single phase of a project. Quantifying the sizes of different reinforcing loop impacts on project durations in a simple but realistic project model can be used to clearly show and explain the magnitude of these impacts to project management practitioners and students, and thereby the importance of using system dynamics in project management.

This is a more formal and thorough look at some issues that I raised a while ago, here and here.

I think one important aspect of the model outcome goes unstated in the paper. The results show dominance of the rework parameter:

The graph shows that, regardless of the value of the variables, the rework cycle has the most impact on project duration, ranging from 1.2 to 26.5 times more than the next most influential loop. As the high level of the variables increases, the impact of “haste makes waste” and “ripple effects” loops increases.

projectcauses

Yes, but why? I think the answer is in the nonlinear relationships among the loops. Here’s a simplified view (omitting some redundant loops for simplicity):

projectrework

Project failure occurs when it crosses the tipping point at which completing one task creates more than one task of rework (red flows). Some rework is inevitable due to the error rate (“rework fraction” – orange), i.e. the inverse of quality. A high rework fraction, all by itself, can torpedo the project.

The ripple effect is a little different – it creates new tasks in proportion to the discovery of rework (blue). This is a multiplicative relationship,

ripple work ≅ rework fraction * ripple strength

which means that the ripple effect can only cause problems if quality is poor to begin with.

Similarly, schedule pressure (green) only contributes to rework when backlogs are large and work accomplished is small relative to scheduled ambitions. For that to happen, one of two things must occur: rework and ripple effects delay completion, or the schedule is too ambitious at the outset.

With this structure, you can see why rework (quality) is a problem in itself, but ripple and schedule effects are contingent on the rework trigger. I haven’t run the simulations to prove it, but I think that explains the dominance of the rework parameter in the results. (There’s a followup article here!)

Update, H/T Michael Bean:

Update II

There’s a nice description of the tipping point dynamics here.

Samuelson’s Multiplier Accelerator

This is a fairly direct implementation of the multiplier-accelerator model from Paul Samuelson’s classic 1939 paper,

“Interactions between the Multiplier Analysis and the Principle of Acceleration” PA Samuelson – The Review of Economics and Statistics, 1939 (paywalled on JSTOR, but if you register you can read a limited number of publications for free)

SamuelsonDiagramB

This is a nice example of very early economic dynamics analyses, and also demonstrates implementation of discrete time notation in Vensim. Continue reading “Samuelson’s Multiplier Accelerator”

Environmental Homeostasis

Replicated from

The Emergence of Environmental Homeostasis in Complex Ecosystems

The Earth, with its core-driven magnetic field, convective mantle, mobile lid tectonics, oceans of liquid water, dynamic climate and abundant life is arguably the most complex system in the known universe. This system has exhibited stability in the sense of, bar a number of notable exceptions, surface temperature remaining within the bounds required for liquid water and so a significant biosphere. Explanations for this range from anthropic principles in which the Earth was essentially lucky, to homeostatic Gaia in which the abiotic and biotic components of the Earth system self-organise into homeostatic states that are robust to a wide range of external perturbations. Here we present results from a conceptual model that demonstrates the emergence of homeostasis as a consequence of the feedback loop operating between life and its environment. Formulating the model in terms of Gaussian processes allows the development of novel computational methods in order to provide solutions. We find that the stability of this system will typically increase then remain constant with an increase in biological diversity and that the number of attractors within the phase space exponentially increases with the number of environmental variables while the probability of the system being in an attractor that lies within prescribed boundaries decreases approximately linearly. We argue that the cybernetic concept of rein control provides insights into how this model system, and potentially any system that is comprised of biological to environmental feedback loops, self-organises into homeostatic states.

See my related blog post for details.

Continue reading “Environmental Homeostasis”

Wonderland

Wonderland model by Sanderson et al.; see Alexandra Milik, Alexia Prskawetz, Gustav Feichtinger, and Warren C. Sanderson, “Slow-fast Dynamics in Wonderland,” Environmental Modeling and Assessment 1 (1996) 3-17.

Here’s an excerpt from my 1998 critique of this model: Continue reading “Wonderland”

Early warnings of catastrophe

Catastrophic Collapse Can Occur without Early Warning: Examples of Silent Catastrophes in Structured Ecological Models (PLOS ONE – open access)

Catastrophic and sudden collapses of ecosystems are sometimes preceded by early warning signals that potentially could be used to predict and prevent a forthcoming catastrophe. Universality of these early warning signals has been proposed, but no formal proof has been provided. Here, we show that in relatively simple ecological models the most commonly used early warning signals for a catastrophic collapse can be silent. We underpin the mathematical reason for this phenomenon, which involves the direction of the eigenvectors of the system. Our results demonstrate that claims on the universality of early warning signals are not correct, and that catastrophic collapses can occur without prior warning. In order to correctly predict a collapse and determine whether early warning signals precede the collapse, detailed knowledge of the mathematical structure of the approaching bifurcation is necessary. Unfortunately, such knowledge is often only obtained after the collapse has already occurred.

This is a third-order ecological model with juvenile and adult prey and a predator:

See my related blog post on the topic, in which I also mention a generic model of critical slowing down.

The model, with changes files (.cin) implementing some of the experiments: CatastropheWarning.zip

Arab Spring

Hard on the heels of commitment comes another interesting, small social dynamics model on Arxiv. This one’s about the dynamics of the Arab Spring.

The self-immolation of Mohamed Bouazizi on December 17, 2011 in the small Tunisian city of Sidi Bouzid, set off a sequence of events culminating in the revolutions of the Arab Spring. It is widely believed that the Internet and social media played a critical role in the growth and success of protests that led to the downfall of the regimes in Egypt and Tunisia. However, the precise mechanisms by which these new media affected the course of events remain unclear. We introduce a simple compartmental model for the dynamics of a revolution in a dictatorial regime such as Tunisia or Egypt which takes into account the role of the Internet and social media. An elementary mathematical analysis of the model identifies four main parameter regions: stable police state, meta-stable police state, unstable police state, and failed state. We illustrate how these regions capture, at least qualitatively, a wide range of scenarios observed in the context of revolutionary movements by considering the revolutions in Tunisia and Egypt, as well as the situation in Iran, China, and Somalia, as case studies. We pose four questions about the dynamics of the Arab Spring revolutions and formulate answers informed by the model. We conclude with some possible directions for future work.

http://arxiv.org/abs/1210.1841

The model has two levels, but since non revolutionaries = 1 – revolutionaries, they’re not independent, so it’s effectively first order. This permits thorough analytical exploration of the dynamics.

This model differs from typical SD practice in that the formulations for visibility and policing use simple discrete logic – policing either works or it doesn’t, for example. There are also no explicit perception processes or delays. This keeps things simple for analysis, but also makes the behavior somewhat bang-bang. An interesting extension of this model would be to explore more operational, behavioral decision rules.

The model can be used as is to replicate the experiments in Figs. 8 & 9. Further experiments in the paper – including parameter changes that reflect social media – should also be replicable, but would take a little extra structure or Synthesim overrides.

This model runs with any recent Vensim version.

ArabSpring1.mdl

ArabSpring1.vpm

I’d especially welcome comments on the model and analysis from people who know the history of events better than I do.

Encouraging Moderation

An interesting paper on Arxiv caught my eye the other day. It uses a simple model of a bipolar debate to explore policies that encourage moderation.

Some of the most pivotal moments in intellectual history occur when a new ideology sweeps through a society, supplanting an established system of beliefs in a rapid revolution of thought. Yet in many cases the new ideology is as extreme as the old. Why is it then that moderate positions so rarely prevail? Here, in the context of a simple model of opinion spreading, we test seven plausible strategies for deradicalizing a society and find that only one of them significantly expands the moderate subpopulation without risking its extinction in the process.

This is a very simple and stylized model, but in the best tradition of model-based theorizing, it yields provocative counter-intuitive results and raises lots of interesting questions. Technology Review’s Arxiv Blog has a nice qualitative take on the work.

See also: Dynamics of Scientific Revolutions, Bifurcations & Filter Bubbles

The model runs in discrete time, but I’ve added implicit rate constants for dimensional consistency in continuous time.

commitment2.mdl & commitment2.vpm

These should be runnable with any Vensim version.

If you add the asymmetric generalizations in the paper’s Supplemental Material, add your name to the model diagram, forward a copy back to me, and I’ll post the update.

Social network valuation with logistic models

This is a logistic growth model for Facebook’s user base, with a very simple financial projection attached. It’s inspired by:

Quis pendit ipsa pretia: facebook valuation and diagnostic of a bubble based on nonlinear demographic dynamics

Peter Cauwels, Didier Sornette

We present a novel methodology to determine the fundamental value of firms in the social-networking sector based on two ingredients: (i) revenues and profits are inherently linked to its user basis through a direct channel that has no equivalent in other sectors; (ii) the growth of the number of users can be calibrated with standard logistic growth models and allows for reliable extrapolations of the size of the business at long time horizons. We illustrate the methodology with a detailed analysis of facebook, one of the biggest of the social-media giants. There is a clear signature of a change of regime that occurred in 2010 on the growth of the number of users, from a pure exponential behavior (a paradigm for unlimited growth) to a logistic function with asymptotic plateau (a paradigm for growth in competition). We consider three different scenarios, a base case, a high growth and an extreme growth scenario. Using a discount factor of 5%, a profit margin of 29% and 3.5 USD of revenues per user per year yields a value of facebook of 15.3 billion USD in the base case scenario, 20.2 billion USD in the high growth scenario and 32.9 billion USD in the extreme growth scenario. According to our methodology, this would imply that facebook would need to increase its profit per user before the IPO by a factor of 3 to 6 in the base case scenario, 2.5 to 5 in the high growth scenario and 1.5 to 3 in the extreme growth scenario in order to meet the current, widespread, high expectations. …

(via the arXiv blog)

This is not an exact replication of the model (though you can plug in the parameters from C&S’ paper to replicate their results). I used slightly different estimation methods, a generalization of the logistic (for saturation exponent <> 1), and variable revenues and interest rates in the projections (also optional).

This is a good illustration of how calibration payoffs work. The payoff in this model is actually a policy payoff, because the weighted sum-squared-error is calculated explicitly in the model. That makes it possible to generate Monte Carlo samples and filter them by SSE, and also makes it easier to estimate the scale and variation in the standard error of user base reports.

The model is connected to input data in a spreadsheet. Most is drawn from the paper, but I updated users and revenues with the latest estimates I could find.

A command script replicates optimization runs that fit the model to data for various values of the user carrying capacity K.

Note that there are two views, one for users, and one for financial projections.

See my accompanying blog post for some reflections on the outcome.

This model requires Vensim DSS, Pro, or the Model Reader. facebook 3.vpm or facebook3.zip (The .zip is probably easier if you have DSS or Pro and want to work with the supplementary control files.)

Update: I’ve added another set of models for Groupon: groupon 1.vpmgroupon 2.vpm and groupon.zip groupon3.zip

See my latest blog post for details.